Texas A&M's star RB Isaiah Spiller carted off with ankle injury against South Carolina

Spiller is the Aggies' leading rusher this season, with 463 yards and five touchdowns on 92 carries.

The injury occurred in the first quarter of A&M's game against South Carolina on Saturday night. Spiller was running the ball up the middle when he was tackled by South Carolina linebacker Sherrod Greene. Spiller immediately grabbed his right ankle and went down in pain. He was helped off the field by trainers and did not return to the game.

The severity of Spiller's injury is not yet known, but it is a major blow to the Aggies' offense. Spiller is one of the most talented running backs in the country, and his absence will be felt in a big way.

ESPN reported that Spiller is expected to miss the rest of the season.

The Aggies are now 3-2 on the season and will face Mississippi State next Saturday.